Oxygenated derivatives of cholesterol (oxysterols) are widely distributed in nature, being found in the blood and tissues of animals and man as well as in foodstuff. They exhibit many biological activities which are of potential physiological, pathological or pharmacological importance. Many oxysterols have been found to be potent inhibitors of cholesterol biosynthesis and one or more oxysterols may play a role as the physiologic feedback regulator of cholesterol synthesis. Oxysterols also inhibit cell replication and have cytotoxic properties effects which suggest (...) that these sterols may participate in the regulation of cell proliferation and may be potentially useful as therapeutic agents for cancer. Furthermore, there is considerable evidence that oxysterols may be involved in the pathogenesis of atherosclerosis. Although the mechanism of action of oxysterols in all these instances is not well understood, the existence of cytosolic and microsomal proteins which bind oxysterols with high affinity and specificity suggests that this group of compounds may represent a family of intracellular regulatory molecules. (shrink)

Michael A. Petersa and Fazal Rizvib aBeijing Normal University, Beijing, PR China; bMelbourne University, Melbourne, Australia Our minds are still racing back and forth, longing for a return to ‘no...

In this paper, we explore the literature on cognitive heuristics and biases in light of virtue epistemology, specifically highlighting the two major positions—agent-reliabilism and agent-responsibilism —as they apply to dual systems theories of cognition and the role of motivation in biases. We investigate under which conditions heuristics and biases might be characterized as vicious and conclude that a certain kind of intellectual arrogance can be attributed to an inappropriate reliance on Type 1, or the improper function of Type 2, cognitive (...) processes. By the same token, the proper intervention of Type 2 processes results in the virtuous functioning of our cognitive systems. Moreover, the role of motivation in attenuating cognitive biases and the cultivation of certain epistemic habits points to the tenets of agent-responsibilism.. (shrink)

Among the works on ethics in the Aristotelian corpus, there is no serious dispute among scholars that the "Eudemian Ethics "is authentic. The "Eudemian Ethics "is" "increasingly read and used by scholars as a useful support and confirmation and sometimes contrast to the "Nicomachean Ethics." Yet, it remains a largely neglected work in the study of Aristotle's ethics, both among scholars and moral philosophers. Peter L. P. Simpson provides an analytical outline of the entire work together with summaries of (...) each individual section, making the overall structure and detailed argument clear. His translation and explanatory notes include the common books that the "Eudemian" "Ethics" shares with the "Nicomachean." This translation contains renderings of words and phrases, and proposals for emending the text that differ from what other translators and scholars have adopted. This translation is literal, without expansion or paraphrase, and yet also readable. A readable but literal translation is necessary because in the "Eudemian Ethics," more than usual in Aristotle's writings, the logic of the argumentation can turn on the peculiar wording or order. Simpson explains the argumentation where necessary in notes and separate explanatory comments. This book is a fresh, twenty-first-century rendition of the work of one of the most eminent philosophers of all time. (shrink)

The study of intellectual humility is still in its early stages and issues of definition and measurement are only now being explored. To inform and guide the process of defining and measuring this important intellectual virtue, we conducted a series of studies into the implicit theory – or ‘folk’ understanding – of an intellectually humble person, a wise person, and an intellectually arrogant person. In Study 1, 350 adults used a free-listing procedure to generate a list of descriptors, one for (...) each person-concept. In Study 2, 335 adults rated the previously generated descriptors by how characteristic each was of the target person-concept. In Study 3, 344 adults sorted the descriptors by similarity for each person-concept. By comparing and contrasting the three person-concepts, a complex portrait of an intellectually humble person emerges with particular epistemic, self-oriented, and other-oriented dimensions. (shrink)

It has been maintained that we are quite able to express (1*)–(4*) without the introduction of a dyadic deontic operator, provided only that we supply our standard deontic logic with a stronger conditional than material implication. The lesson learned from Chisholm's paradox has been the eminently convincing, indeed obvious, one: that what we ought to do is not determined by what is the case in some perfect world, but by what is the case in the best world we can ‘get (...) to’ from this world. What we ought to do depends upon how we are circumstanced. (shrink)

In this follow up to The Eudemian Ethics of Aristotle, Peter L. P. Simpson centers his attention on the basics of Aristotelian moral doctrine as found in the Great Ethics: the definition of happiness, the nature and kind of the virtues, pleasure, and friendship. This work's authenticity is disputed, but Simpson argues that all the evidence favors it. Unlike the Nicomachean and Eudemian Ethics, Aristotle wrote the Great Ethics for a popular audience. It gives us insight less into Aristotle (...) the theoretician than into Aristotle the pedagogue. For this reason, the Great Ethics has distinct advantages as an introduction to Aristotelian ethical thinking: it is simpler and clearer in its argumentation, matters such as the intellectual virtues are made suitably secondary to the practical focus, the moral virtues come through with a pleasing directness, and the work's syllogistic formalism gives it a transparency and accessibility that the other Ethics typically lack. Arius' Epitome, which relies heavily on this work, helps confirm its value and authenticity. Because the Great Ethics is generally neglected by scholars, less has been done to clear up its obscurities or to expose its structure. But to ignore it is to lose another and more instructive way of approaching and appreciating Aristotle's teaching. The translation is prefaced by an analytic outline of the whole, and the several sections of it are prefaced by brief summaries. The commentary supplies fuller descriptions and analyses, sorting out puzzles, removing misunderstandings, and resolving doubts of meaning and intention. This book is a fresh rendition of the work of the preeminent philosopher of all time. (shrink)

This paper began with the simple object of finding an account that allowed us to compare incompatible false theories. This we achieved with ρ. But that relation is language — or interest — dependent. ρ' is free from this limitation; though thus liberated it is perhaps rather unconcerned about what is true, and further fails to deliver certain intuitive comparisons. Whether ρ is to be preferred to ρ' or vice versa, seems to me a largely fruitless question: In fact it (...) might be that as we seek to free the idea of verisimilitude from any dependence on language, interests or problems, so we gradually collapse it to nothing more than logical power. (shrink)

Guanxi, or social networks common in Confucian cultures, has long been recognized as one of the major factors for success when doing business in China. However, insider networks in business are certainly not confined to Asian cultures, nor is the attendant possibility for corruption. This study obtained original data to investigate current Taiwanese perceptions of (1) how guanxi is established and cultivated; (2) how guanxi actually is practiced now and people’s acceptance of it; and (3) the effects of guanxi on (...) business operations, employment/promotion, and social justice and fairness. The researchers also hope to (4) verify some arguments made by pioneering researchers. The authors speculate on how these attitudes may affect behavior in business transactions in hopes of making readers more aware of differing cultural values that may create unexpected ethical dilemmas. They suggest that professional ethical codes should provide guidance on the practice of guanxi in a Confucian society and that special emphasis or training in interpreting those codes may be required. (shrink)

The many gods of modernity -- The dynamics of relativization -- Relativism -- Fundamentalism -- Certainty and doubt -- The limits of doubt -- The politics of moderation.

ABSTRACT:In this paper we examine how ethical values contribute to national economic prosperity. We extend the concept of an ethical wealth of nations first introduced by Donaldson in which he proposed four categories of ethical values—fairer distribution of goods, better government, ingrained social cooperation, and inculcation of economic duties—that can drive economic performance, but only if citizens ascribe “intrinsic value” to them independent of their economic interests. Our analysis draws on institutional economics and sociology research to show that if ethical (...) values are to drive economic performance, they must also be supported by the institutional fabric of the nation. We embed an expanded set of ethical values in a set of democratic, free market and civil society institutions spanning three sectors of society—political, economic and cultural respectively. We conclude by discussing the implications of our institutional framework for moral education. (shrink)

The income and careers that come with building wind turbines have become a lifeline for many factory towns and farming communities. Generating electricity from the wind puts increasingly cheap power on the grid, saving consumers billions a year. And it is one of the biggest, fastest, cheapest ways to reduce carbon pollution, reducing the threat of climate change. Yet as wind farms have rapidly spread to forty‐one states, their developers must make their case anew with each community that hosts them. (...) Facts matter, but so do empathy, honoring deep connections to neighbors and landscape, and developing mutual respect. Successful wind farm developers listen first for shared values and speak with inclusive language, to communicate with potential opponents across divides of misunderstanding and motivate local residents to adapt to and benefit from change. (shrink)

D. W. Winnicott is increasingly recognized as one of the most important psychoanalysts since Freud, but the relevance of his Independent version of object relations theory to psychoanalytic literary criticism has not been sufficiently appreciated. As Peter L. Rudnytsky notes, "There must be ten literary critics conversant with Lacan's ecrits for every one who has read Winnicott's Playing and Reality." Transitional Objects and Potential Spaces begins to redress this imbalance. The title and subtitle of this collection highlight three of (...) Winnicott's key concepts: transitional objects, potential space, and the use of an object. Because Winnicott is unique in respecting the integrity of art as an autonomous human activity while continuing to insist on its infantile origins, he may be said to offer the first adequate psychoanalytic account of aesthetics. This volume is organized into three sections: The Analytic Frame, Literary Objects, and Cultural Fields. Beginning with Winnicott's "The Location of Cultural Experience," it features essays by a distinguished group of contributors, including Marion Milner and two current leading members of the British Psycho-Analytical Society, Christopher Bollas and Patrick J. Casement, as well as such eminent critics as Richard Poirier, Murray M. Schwartz, Ellen Handler Spitz, and Madelon Sprengnether. Transitional Objects and Potential Spaces makes a timely and persuasive case for the power of Winnicott's ideas. In defining for the first time an independent tradition of psychoanalytic criticism, it will reorient future work in literary and cultural studies. (shrink)

A polemical and reductionist critical response to Skinner and Pocock has inhibited an appreciation of the true potential of their historiographical discussions for the practice of political theories. An important step in understanding the history of political thought in its duality - as both being about acts of political discourse over time and as itself being political - is to recognize the "traditionary" nature of discursive acts. Following Pocock and Skinner, we should speak not of tradition as objects carried on, (...) but of the nature of that carrying on, that activity of handing down through language. A traditionary act involves subscription to a fairly sophisticated account of the development of a particular form of practices through time and the identification by the actor of his act as part of that development. This subscription allows us to overcome the categorical dichotomies such as history versus philosophy, autonomy of texts versus ideas as expressions of social relations, voluntarism versus determinism, and language as either restrictive or instrumental, which underlie much of the contemporary methodological dispute. (shrink)

Participants of low and high hypnotic susceptibility were tested on a temporal order judgement task, both with and without hypnosis. Judgements were made of the order of presentation of light flashes appearing in first one hemi-field then the other. There were differences in the inter-stimulus intervals required accurately to report the order, depending upon which hemi-field led. This asymmetry was most marked in hypnotically susceptible participants and reversed when they were hypnotised. This implies not only that brain activity changes in (...) hypnosis, but also that there is a difference in brain function between people of low and high hypnotic susceptibility. The latter exhibited a faster-acting left hemisphere in the waking state, but faster right when hypnotised. (shrink)

Aus dem Zusammentreffen der Philosophischen Anthropologie mit der interdisziplinären Rhetorikforschung sind heute zwei neue komplementäre Tochterdisziplinen entstanden. Die eine ist die fundamentalrhetorische Anthropologie, welche den Menschen generell als homo rhetoricus definiert. Die andere klärt als rhetorische Metakritik die Philosophie selbst über ihre eigene, immanente Rhetorizität auf. Der vorliegende Band präsentiert exemplarische Beiträge zu diesem neuen rhetorischen Denken in zwei Teilen. Der erste enthält unter dem Titel „Zur Philosophie der Rhetorik“ die Arbeiten zur fundamentalrhetorischen Anthropologie. Ausgehend von grundlegenden Thesen zur Homo-rhetoricus-Anthropologie (...) behandeln sie Themen wie z.B. Pithanologie, Pathelogie, Polypersonalität, Anthropotechnik, Autoinvenienz oder die Rekonstruktion des Subjektbegriffes durch interne Rhetorik. Der zweite Teil „Zur Rhetorik der Philosophie“ umfasst die Beiträge, welche der rhetorischen Metakritik der Philosophie und ihrer Geschichte zuzurechnen sind. Hier finden sich u.a. Abhandlungen zur Topographie der klassischen Metaphysik und ihren sophistischen und pararhetorischen Gegenspielern sowie metakritische Detailstudien zu Pseudo-Longin, Kant, Hegel, Fichte und Heidegger. (shrink)

Actin performs structural as well as motor‐like functions in eukaryotic cells. Orthologues of actin have also been identified in bacteria, where they perform an essential function during cell growth. Bacterial actins are implicated in the maintenance of rod‐shaped cell morphology, and appear to form a cytoskeletal structure, localising as helical filaments underneath the cell membrane. Recently, a plasmid‐borne actin orthologue has been shown to perform a mitotic‐like function during segregation of a plasmid, and chromosomally encoded actin proteins were found to (...) play an important role in chromosome segregation. Based on the findings that actin filaments are dynamic structures in two bacterial species, we propose that actins perform motor functions rather than a purely structural role in bacteria. We suggest that an intracellular motor exists in bacteria that could be derived from an ancestral actin motor that was present in cells early in evolution. BioEssays 26:1209–1216, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Pope John Paul II's opposition to the Iraq War was not that it failed to meet the conditions of Just War Theory. Indeed, we cannot tell from what he publicly said whether he thought it met those conditions or not, for he would have opposed it in any case. His thinking was rather that even just and necessary wars always come, as it were, too late, and are never able to solve the problems that made wars just and necessary. He (...) was not trying therefore to enter into the details of Just War Theory. He wanted to subsume the principles of war into the principles of peace and to do so, not by denying justice, but by transcending it with charity. This article shows how this thinking is to be understood and the many means the Pope devised for putting this thinking into practice. (shrink)

This book emphasizes that analysis of broad economic changes treats people abstractly, while a personalist view sees them as human agents who, while needing and generating economic goods, must still be responsive to others and be aware of values and goals beyond temporal well-being. Visit our website for sample chapters!

An attempt is made to clarify a thought experiment introduced by P. T. Landsberg concerning the relativistic heat flow between bodies in relative motion. It is shown that if the problem is analyzed within the covariant thermodynamics developed by R. Balescu, supplemented by the second law of thermodynamics as proposed here, then such heat flow considerations do not fix the transformation of temperature as Landsberg contends. Instead, the transformation of temperature is left as being purely a matter of definition.